Table 2.
Pharmacokinetic parameters on days 1 and 10 following multiple dose administration of omapatrilat.
| Omapatrilat dose (n = 6/group) | Cmax (ng ml−1) | tmax* (h) | AUC(0,t) (ng ml−1h) | t1/2,eff (h) |
|---|---|---|---|---|
| Day 1 | ||||
| 10 mg | 9.6 | 1.5 | 19.5 | NA |
| (5.5) | (1.0, 4.0) | (6.8) | ||
| 25 mg | 26.4 | 1.0 | 63.8 | NA |
| (8.9) | (1.0, 2.5) | (16.9) | ||
| 50 mg | 93.5 | 0.8 | 147.9 | NA |
| (58.5) | (0.5, 4.0) | (32.2) | ||
| 75 mg | 181.7 | 0.5 | 341.6 | NA |
| (98.7) | (0.5, 3.0) | (100.7) | ||
| 125 mg | 203.3 | 0.5 | 369.4 | NA |
| (112.5) | (0.5, 3.0) | (124.0) | ||
| Day 10 | ||||
| 10 mg | 14.4 | 0.8 | 30.1 | 19.3 |
| (6.1) | (0.5, 3.0) | (6.3) | (17.1) | |
| 25 mg | 80.7 | 0.5 | 92.4 | 17.4 |
| (46.9) | (0.5, 2.0) | (20.1) | (9.7) | |
| 50 mg | 175.9 | 2.0 | 226.9 | 17.1 |
| (105.6) | (0.5, 4.0) | (43.0) | (11.6) | |
| 75 mg | 297.1 | 1.5 | 420.9 | 14.3 |
| (144.2) | (0.5, 4.0) | (55.4) | (8.9) | |
| 125 mg† | 895.3 | 0.5 | 745.2 | NA |
| (284.2) | (0.5, 0.5) | (125.3) |
Results are presented as mean (SD)
*
Median (minimum, maximum); NA = not available
†
n = 2