Table 3.
Daily urinary excretion of ANP following a) single and b) multiple doses of omapatrilat.
| a) Omapatrilat dose (Single-dose study) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Placebo | 2.5 mg | 7.5 mg | 25 mg | 50 mg | 125 mg | 250 mg | 500 mg | |
| Urinary ANP | 10.8 | 12.2 | 15.9 | 26.2 | 34.1 | 45.9 | 55.0 | 60.0 |
| (ng 24 h−1) | (4.1) | (6.0) | (1.7) | (3.8) | (13.8) | (9.4) | (14.0) | (18.2) |
| b) Omapatrilat dose (Multiple-dose study) | |||||||
|---|---|---|---|---|---|---|---|
| Day | Placebo | 10 mg | 25 mg | 50 mg | 75 mg | 125 mg | |
| Urinary ANP | Pre-dose | 9.4 | 11.3 | 10.5 | 12.5 | 10.6 | 9.3 |
| (ng 24 h−1) | (2.8) | (4.0) | (3.9) | (4.7) | (2.7) | (2.7) | |
| Urinary ANP | Day 1 | 10.7 | 16.3 | 32.2 | 37.0 | 31.9 | 47.2 |
| (ng 24 h−1) | (3.5) | (5.3) | (11.0) | (8.7) | (8.2) | (10.4) | |
| Urinary ANP | Day 3 | 9.3 | NS | 29.2 | 37.2 | 41.6 | 42.1 |
| (ng 24 h−1) | (2.9) | (11.0) | (14.0) | (7.8) | (15.3) | ||
| Urinary ANP | Day 10 | 9.7 | 16.9 | 29.4 | 30.3 | 33.3 | 33.8* |
| (ng 24 h−1) | (2.8) | (3.4) | (8.6) | (8.7) | (7.2) | (13.2) | |
Results are presented as mean (SD); NS: No samples collected
*
n = 2