Table 4.

Urinary sodium and potassium excretion and volume following administration of omapatrilat.

	Sodium (mEq day−1)				Potassium (mEq day−1)				Urinary volume (l day−1)
Treatment	Day −1	Day 1	Day 3	Day 10	Day −1	Day 1	Day 3	Day 10	Day −1	Day 1	Day 3	Day 10
Placebo	175	160	166	134	71	97	87	99	2.38	2.03	2.26	1.96
(n = 15)	(38)	(59)	(31)	(39)	(14)	(25)	(20)	(34)	(0.64)	(0.57)	(0.34)	(0.44)
10 mg	200	174	NS	132	79	78	NS	95	2.60	2.24	NS	2.13
	(38)	(44)		(38)	(16)	(13)		(13)	(0.35)	(0.54)		(0.56)
25 mg	216	195	192	158	61	80	78	86	2.39	2.15	2.32	1.91
	(36)	(42)	(32)	(23)	(15)	(23)	(3)	(15)	(0.45)	(0.55)	(0.43)	(0.26)
50 mg	222	188	215	143	70	84	107	89	2.85	2.56	2.68	1.97
	(37)	(20)	(33)	(42)	(20)	(14)	(16)	(20)	(0.54)	(0.38)	(0.41)	(0.43)
75 mg	187	125	203	160	73	71	83	87	2.62	1.73	2.51	1.96
	(48)	(17)	(26)	(28)	(12)	(16)	(10)	(8)	(0.29)	(0.33)	(0.21)	(0.17)
125 mg	176	189	181	182*	69	80	82†	105*	2.26	2.46	2.68	2.24*
	(25)	(32)	(40)	(37)	(17)	(20)	(10)	(11)	(0.33)	(0.38)	(0.52)	(0.38)

Results are presented as mean (SD); NS: no sample collected for subjects in 10 mg dose group

^*n = 2

^†n = 4