Table 2.
NONMEM estimates of population pharmacokinetic parameters (whole data set, 448 patients).
| Final model | Bootstrap (n = 500) | ||||
|---|---|---|---|---|---|
| Parameter | Estimates | 95% CI | Median | 95% CI | |
| Clearance (l h−1) | 0.733 | 0.698–0.738 | 0.734 | 0.702–0.766 | |
| WT (θ5) | 4.32 × 10−3 | 1.13 × 10−3–7.51 × 10−3 | 4.47 × 10−3 | 1.39 × 10−3–7.65 × 10−3 | |
| CRCL (θ6) | 3.38 × 10−3 | 1.76 × 10−3–5.00 × 10−3 | 3.38 × 10−3 | 1.77 × 10−3–5.01 × 10−3 | |
| V (l) | 5.24 | 4.20–6.28 | 5.19 | 2.55–6.59 | |
| Ka (h−1) | 0.235 | 0.157–0.313 | 0.232 | 0.149–0.361 | |
| ωCL (%) | 26.9 | 20.9–31.8 | 26.6 | 20.3–31.8 | |
| πCL (%) | 21.7 | 14.9–26.8 | 21.7 | 12.3–27.2 | |
| ωV (%) | 56.1 | 36.4–70.6 | 55.8 | 34.2–77.2 | |
| σ (%) | 21.5 | 16.4–25.6 | 21.3 | 16.5–25.6 | |
95% CI, Confidence interval calculated from parameter standard errors (final model) or as 2.5th and 97.5th percentiles of bootstrap estimates; WT, weight; CRCL, creatinine clearance; V, apparent volume of distribution; Ka, absorption rate; ω, coefficient of variation of interindividual variability;π, coefficient of variation of intraindividual variability;σ coefficient of variation of residual error.