Table 3.

Logistic regression models for the probability of haemorrhage.

		Model		Bootstrap (n = 5000)
Endpoint	Covariate	Odds ratio* (95% CI)	P	Odds ratio* (95% CI)
All haemorrhage†	CL	0.800 (0.702–0.917)	0.0013	0.803 (0.683–0.920)
Major haemorrhage‡	CL	0.505 (0.346–0.735)	0.0004	0.499 (0.275–0.707)

^*Odds ratio for a 0.1 unit change in clearance (i.e. 13% of mean CL), point estimate of the model and median of the 5000 bootstraps.

^†Incidence 10.7% (48/448 patients).

^‡Incidence 2.2% (10/448). CI, Confidence interval; CL, apparent clearance.