Table 4.

Population pharmacokinetics and logistic regression model predictions.

		Increased odds compared with median
Creatinine clearance (ml min−1)	Clearance (l h−1)	All haemorrhage	Major haemorrhage*
85.7 (median)	0.733† (typical)	1.00	1.00
–	0.390 (5th percentile)	2.14	10.4
50 (upper limit moderate renal impairment)	0.605† (17% decrease)	1.33	2.39
30‡ (upper limit severe renal impairment)	0.537† (27% decrease)	1.54	3.81
42.5 (median of patients with creatinine clearance <50)§	0.581† (21% decrease)	1.40	2.83

^*Prediction for major haemorrhage should be taken with caution due to the small number of events in the database.

^†Population pharmacokinetic model predictions.

^‡Predictions may not be valid because of the small number of patients in the database (n = 4).

^§Median of n = 55 patients in the database.