Table 2.
Subcutaneous interstitial fluid-to-plasma partition coefficient (Kp) of fluconazole determined as the ratio of the area under the curve of subcutaneous interstitial fluid concentration to the area under the curve of unbound plasma concentration obtained from 8 h sampling (AUCSCIF (0,8 h) : AUCunbound plasma (0,8 h).
| Subject | AUCunbound plasma(0,8 h) (µg l−1h) | AUCSCIF(0,8 h) (µg l−1h) | Kp |
|---|---|---|---|
| 1 | 18.74 | 19.04 | 1.02 |
| 2 | 17.68 | 26.04 | 1.47 |
| 3 | 14.26 | 16.02 | 1.12 |
| 4 | 24.89 | 31.80 | 1.28 |
| 5 | 27.92 | 25.24 | 0.90 |
| Mean | 20.70 | 23.63 | 1.16 |
| SD | 5.57 | 6.21 | 0.22 |