Table 4.
Period Placebo | Stiripentol | 95% confidence interval on differences | ||
---|---|---|---|---|
Tmax (h) | 1.2 ± 0.6 | 0.92 ± 0.2 | NS | 0, 0* |
Cmax (ng ml−1) | 149.3 ± 83.2 | 149.7 ± 82.4 | – | |
log Cmax | 4.86 ± 0.58 | 4.84 ± 0.65 | NS | −39.8, +39.8† |
AUC (ng h ml−1) | 229.4 ± 131.8 | 269.0 ± 189.0 | – | |
log AUC | 5.23 ± 0.75 | 5.31 ± 0.84 | NS | −33.2, +112† |
CL/F (l h−1) | 1.90 ± 1.12 | 2.43 ± 1.90 | NS | −0.873, +1.59† |
t1/2 (h) | 1.12 ± 0.65 | 1.44 ± 0.93 | NS | −0.33, +0.97† |
AUC, Area under the plasma concentration-time curve from 0 to 12 h; Cmax, maximum plasma concentration; tmax, time to reach Cmax; CL/F, apparent clearance; t1/2, half-life; NS, not significant.
Binomial confidence interval.
Student's confidence interval.