Table 2.
Cysteamine compartmental pharmacokinetic parameter estimates.
| CL/F, ml min-1 kg−1 | Vc, l kg−1 | Q, ml min−1 kg−1 | Vss/F, l kg−1 | Ka, h−1 | Alag, h | |
|---|---|---|---|---|---|---|
| Mean | 32.3 | 2.0 | 29.8 | 15.1 | 1.7 | 0.44 |
| Geometric mean | 30.6 | 1.6 | 24.6 | 11.0 | 1.6 | 0.41 |
| Median | 29.1 | 1.7 | 22.5 | 9.9 | 1.7 | 0.36 |
| Minimum | 17.3 | 0.1 | 8.7 | 2.7 | 0.7 | 0.22 |
| Maximum | 52.2 | 3.6 | 83.1 | 32.3 | 2.5 | 0.92 |
CL/F, Apparent clearance; Vc, volume of the central compartment; Q, intercompartmental clearance; Vss/F, apparent steady-state volume of distribution; Ka, absorption rate constant; Alag, absorption lag time.