Table 3.

White blood cell cystine pharmacodynamic parameter estimates.

	EC50, µM	Ke0, h−1	BL cystine, nmol cystine mg−1 protein
Mean	15.3	2.2	0.91
Median	6.5	1.4	0.79
Geometric mean	5.6	1.3	0.76
Minimum	0.6	0.2	0.13
Maximum	61.1	8.9	1.9

EC50, Concentration producing 50% of maximal effect; Ke0, elimination rate constant from the theoretical effect compartment; BL, baseline (predose) cystine content.