Table 3.

Ambulatory BP for the per protocol population.

	Baseline ± SD (mmHg)	Mean change ± SD (mmHg)		Least-squares mean difference ± SE (mmHg)		Upper & lower 95% confidence interval		P value
Treatment group	DBP	DBP	SBP	DBP	SBP	DBP	SBP	DBP & SBP
24 h
Placebo	92.3 ± 5.6	0.2 ± 3.6	0.2 ± 6.0
40 mg	93.5 ± 6.1	−3.6 ± 5.3	−5.8 ± 8.2	−3.7 ± 0.9	−5.7 ± 1.5	−5.6, −1.8	−8.8, −2.7	< 0.001
80 mg	94.2 ± 7.2	−4.0 ± 5.4	−7.4 ± 8.7	−3.9 ± 0.9	−7.1 ± 1.5	−5.8, −2.1	−10.1, −4.0	< 0.001
160 mg	94.9 ± 7.3	−4.7 ± 5.3	−8.1 ± 9.1	−4.4 ± 1.0	−7.1 ± 1.6	−6.3, −2.5	−10.3, −4.0	< 0.001
Daytime
Placebo	98.7 ± 4.9	−0.6 ± 4.6	−1.1 ± 7.8
40 mg	99.5 ± 6.4	−4.7 ± 5.6	−7.2 ± 8.7	−4.2 ± 1.1	−5.9 ± 1.7	6.2, −2.1	−9.3, −2.6	< 0.001
80 mg	100.6 ± 7.1	−5.3 ± 5.8	−9.6 ± 8.9	−4.3 ± 1.0	−7.7 ± 1.7	−6.4, −2.3	−11.0, −4.4	< 0.001
160 mg	100.3 ± 7.7	−4.9 ± 6.3	−8.8 ± 10.2	−4.0 ± 1.1	−6.4 ± 1.7	−6.1, −1.9	−9.8, −3.0	< 0.001
Night-time
Placebo	83.5 ± 8.1	1.2 ± 4.5	1.9 ± 7.2
40 mg	84.8 ± 7.4	−1.9 ± 6	−3.6 ± 9.2	−2.8 ± 1.1	−5.1 ± 1.8	−5.0, −0.6	−8.6, −1.5	< 0.014
80 mg	85.1 ± 8.9	−2.2 ± 6.3	−4.2 ± 10.1	−3.2 ± 1.1	−5.8 ± 1.8	−5.4, −0.1	−9.3, −2.3	< 0.004
160 mg	87.3 ± 8.9	−4.3 ± 6.4	−7.1 ± 10.6	−4.7 ± 1.2	−7.6 ± 1.9	−7.0, −2.4	−11.3, −4.0	< 0.001