Table 2.

Effects of immunization on both the anti-(AI) IgG titres and mean arterial blood pressure (MBP) response to AI or AII challenge in Study A rats.

		Peak change in MBP (mmHg) over all doses of agonist
Treatment and AI dose	Anti-AI IgG titre	AI	AII
Saline control (0 µg)	0	25.5 ± 2.8	24.3 ± 1.6
PMD2850 (25 µg)	55629 ± 14414	15.4 ± 1.7*	22.1 ± 1.5
PMD3117 (10 µg)	66121 ± 13264	13.3 ± 2.4*	15.7 ± 3.0
PMD3117 (50 µg)	67410 ± 7393	13.8 ± 2.8*	19.0 ± 3.3

Significance probabilities (P) were adjusted for the multiple MBP comparisons by Dunnett's method,

^*P < 0.05 vs. the saline control treatment. Values are mean ± SEM, n = 6.