Table 4.
Effects of immunization on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) response to angiotensin I hormone (AI) or angiotensin II hormone (AII) challenge in humans (Study D).
| Change in SBP and DBP (mmHg) at each dose of agonist | ||
|---|---|---|
| AI or AII challenge & dose | SBP | DBP |
| AI (4 ng min−1 kg−1) | −5.7 ± 3.4 (P = 0.12) | −1.1 ± 3.7 (P = 0.76) |
| AI (20 ng min−1 kg−1) | −7.4 ± 4.3 (P = 0.11) | −2.4 ± 2.7 (P = 0.39) |
| AII (1 ng min−1 kg−1) | −1.3 ± 4.3 (P = 0.76) | −0.8 ± 1.8 (P = 0.67) |
| AII (5 ng min−1 kg−1) | −1.8 ± 4.8 (P = 0.72) | −2.3 ± 2.0 (P = 0.29) |
Results shown are from analyses with mean change in SBP and DBP seen in the study subjects to the infused AI or AII doses. Significance probabilities (P) were adjusted for the multiple blood pressure comparisons by a two-sided t-test method vs. the Al(OH)3 control treatment using day −1 response as covariant. Values are mean ± SEM, n = 8.