Table 4.
Pharmacokinetic parameter estimates for lorazepam using the two-compartment model in the learning group.
| Model without covariates | Model with covariates | |||
|---|---|---|---|---|
| Parameter | Estimate | CV (%) | Estimate | CV (%) |
| Estimated parameters | ||||
| CL no alcohol abuse (l h−1) | 3.90 | 102 | 4.13 − (PEEP − 5) × 0.417 | 63 |
| CL alcohol abuse (l h−1) | 1.20 | 606 | 0.74 | 389 |
| V (l) | 0.686 | 141 | 0.743 | 124 |
| Vss (l) | 264 | 209 | 156 − (age − 58) × 2.07 | 117 |
| Q (l h−1) | 32.7 | 79 | 36.3 | 75 |
| Proportional residual error (%) | 22.7 | 15.4 | ||
| Performance measures | ||||
| MDWR (%) | 3.35 | 1.51 | ||
| MDAWR (%) | 14.44 | 13.61 | ||
| Objective function | −2028.44 | −2082.15 | ||
CV coefficient of variation; MDWR median weighted residual; MDAWR median absolute weighted residual.