Table 5.
Pharmacokinetic parameter estimates for midazolam using the two-compartment model in the learning group.
| Model without covariates | Model with covariates | |||
|---|---|---|---|---|
| Parameter | Estimate | CV (%) | Estimate | CV (%) |
| Estimated parameters | ||||
| CL (l h−1) | 9.53 | 104 | ||
| CL no alcohol abuse (l h−1) | 11.3 − (age − 57) × 0.145 | 77 | ||
| CL alcohol abuse (l h−1) | 7.3 − (age − 57) × 0.145 | 77 | ||
| V (l) | 2.04 | 179 | 7.15 | 225 |
| Vss (l) | 364 | 282 | 431 | 355 |
| Q (l h−1) | 47.6 | 66 | 40.8 − (APACHE − 26) × 2.75 | 54 |
| Proportional residual error (%) | 31.9 | 30.9 | ||
| Residual error (ng ml−1) | 46 | 32 | ||
| Performance measures | ||||
| MDWR (%) | 1.22 | 1.22 | ||
| MDAWR (%) | 12.37 | 12.87 | ||
| Objective function | −336.191 | −422.668 | ||
CV coefficient of variation; MDWR median weighted residual; MDAWR median absolute weighted residual.