Table 2.
Ratio of hydroxyperhexiline : perhexiline plasma concentrations for nine patients at each sampling time
| Patient | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Time (h) postdose | 2 | 3 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
| 0 | 2.38 | 1.08 | 5.95 | 1.95 | 4.40 | 4.97 | 8.15 | 4.43 | 13.63 |
| 1 | 2.04 | 1.54 | 5.79 | 1.86 | 4.33 | 6.29 | 7.69 | 4.97 | 13.75 |
| 2 | 2.19 | 1.18 | 6.17 | 1.95 | 4.51 | 3.96 | 8.02 | 4.00 | 16.11 |
| 3 | 2.01 | 1.26 | 5.85 | 2.02 | 4.51 | 5.63 | 7.63 | 3.49 | 12.41 |
| 4 | 2.17 | 1.17 | 6.04 | 1.95 | 4.00 | 6.48 | 7.80 | 3.05 | 10.44 |
| 6 | 2.23 | 1.37 | 5.42 | 1.78 | 3.45 | 6.00 | 8.64 | 3.23 | 8.33 |
| 12 | 1.43 | 4.95 | 1.95 | 4.13 | 6.25 | 17.52 | 3.98 | 15.18 | |
| 24 | 2.81 | 1.31 | 5.4 | 1.83 | 4.34 | 6.95 | 13.73 | 4.41 | 11.64 |
| Mean | 2.26 | 1.29 | 5.70 | 1.91 | 4.21 | 5.82 | 9.90 | 3.94 | 12.69 |
| 95% CI | 0.18 | 0.10 | 0.27 | 0.05 | 0.23 | 0.62 | 2.41 | 0.43 | 1.66 |