Table 1.
Results from studies of patients with falciparum malaria (PF [6]), vivax malaria (PV [7]), healthy Vietnamese volunteers (VV [3]) and healthy Caucasian volunteers (CV [4]). Data are mean ± SD unless otherwise indicated
| Study group [Reference] | ||||
|---|---|---|---|---|
| PF [6] | PV [7] | VV [3] | CV [4] | |
| Numbera | 17 | 5 | 7 | 8 |
| Gender (M/F) | 16/1 | 5/0 | 7/0 | 4/4 |
| Age (years) | 25 ± 6 | 28 ± 11 | 29 ± 7 | 20 ± 1 |
| Body weight (kg) | 50 ± 4 | 50 ± 4 | 52 ± 6 | 61 ± 7b |
| Venous haematocrit (%) | 37 ± 7 | 40 ± 5 | 42 ± 3 | 42 ± 5 |
| Serum creatinine (µmol l−1) | 92 ± 17 | 100 ± 18 | 82 ± 10 | 83 ± 15 |
| Serum bilirubin (µmol l−1) | 19 ± 12c | 9 ± 7 | 8 ± 4 | 9 ± 3 |
| Serum alanine aminotransferase (units l−1) | 36 ± 18 | 31 ± 9 | 52 ± 42 | 15 ± 5 |
| Serum albumin (g l−1) | 39 ± 4d | 44 ± 8 | 49 ± 7 | 48 ± 2 |
| Parasitaemia (per µl) | 17 419 (1 050–333 300)e | 3 782 (460–14 500)e | – | – |
| DHA fraction unbound (fu) | 0.068 ± 0.032 | 0.065 ± 0.009 | 0.117 ± 0.015f | 0.092 ± 0.020 |
| DHA α:β anomer ratio | 6.3 ± 0.9 | 6.9 ± 0.8 | 6.9 ± 0.6 | 5.4 ± 0.8b |
a
Total patients in original studies were: PF = 26; PV = 12; VV = 10; CV = 8;
b
P < 0.05 compared with all other groups (anova),
c
P < 0.05 compared with volunteer groups (VV and CV; anova),
d
n = 5 (mean ± SD albumin in original study was 43 ± 7 g l−1)
e
Geometric mean (range)
f
P < 0.05 compared with patient groups (PF and PV; anova).