Table 3.
Association between previous use of mefloquine, body mass index (BMI) and Profile of Mood States (POMS)*
| Total population | Males | Females | ||||
|---|---|---|---|---|---|---|
| With previous use | Without previous use | With previous use | Without previous use | With previous use | Without previous use | |
| Tension | ||||||
| BMI ≤20 | 0.33 (−7.26, 7.92) | −0.50 (−1.84, 0.84) | 2.00 (−10.71, 14.71) | – | – | −0.36 (−2.12, 1.40) |
| 21–25 | 0.19 (−0.84, 1.21) | 0.52 (−0.42, 1.46) | −0.71 (−2.31, 0.88) | 0.00 (−1.02, 1.02) | 0.89 (−0.50, 2.27) | 1.14 (−0.59, 2.88) |
| >25 | 0.36 (−1.21, 1.94) | −0.55 (−1.33, 0.23) | 0.27 (−2.03, 2.56) | 0.35 (−0.40, 1.10) | 0.57 (−1.27, 2.41) | −1.64 (−2.99, −0.29) |
| Depression | ||||||
| BMI ≤20 | −0.33 (−1.77, 1.10) | 0.43 (−0.41, 1.27) | – | – | – | 0.55 (−0.55, 1.64) |
| –25 | 0.16 (−0.42, 0.74) | 0.87 (−0.32, 2.06) | 0.07 (−0.35, 0.49) | 0.04 (−0.55, 0.63) | 0.22 (−0.81, 1.25) | 1.86 (−0.72, 4.43) |
| >25 | −0.27 (−0.96, 0.41) | 0.26 (−0.20, 0.71) | 0.13 (−0.37, 0.64) | 0.29 (−0.49, 1.08) | −1.14 (−3.24, 0.95) | 0.21 (−0.25, 0.68) |
| Anger | ||||||
| BMI ≤20 | 0.67 (−2.20, 3.54) | 1.79 (−0.89, 4.47) | – | 0.33 (−1.10, 1.77) | – | 2.18 (−1.32, 5.68) |
| 21–25 | −1.78 (−3.74, 0.18) | 0.43 (−0.89, 1.76) | −2.86 (−5.89, 0.17) | −0.56 (−2.11, 0.99) | −0.94 (−3.71, 1.82) | 1.62 (−0.66, 3.90) |
| >25 | 0.00 (−1.09, 1.09) | 0.39 (−0.40, 1.17) | −0.33 (−1.88, 1.21) | 0.59 (−0.46, 1.63) | 0.71 (−0.67, 2.10) | 0.14 (−1.19, 1.48) |
| Fatigue | ||||||
| BMI ≤20 | 1.00 (−1.48, 3.48) | 2.86 (0.51, 5.29) | 1.00 (−11.71, 13.71) | −0.67 (−2.10, 0.77) | – | 3.82 (1.07, 6.57) |
| 21–25 | 0.90 (−0.43, 2.24) | 1.20 (−0.12, 2.52) | 0.07 (−1.80, 1.95) | 0.84 (−0.51, 2.19) | 1.56 (−0.42, 3.53) | 1.62 (−0.93, 4.17) |
| >25 | 0.64 (−0.99, 3.69) | 0.29 (−1.36, 0.78) | 0.93 (−1.11, 2.98) | 0.59 (−1.11, 2.28) | 0.00 (−3.50, 3.50) | 1.36 (−2.53, −0.19) |
| Vigour | ||||||
| BMI ≤20 | −0.67 (−4.46, 3.13) | −2.36 (−3.98, −0.73) | 0.00 (−12.71, 12.71) | −0.33 (−4.13, 3.46) | – | −2.91 (−4.84, −0.97) |
| 21–25 | 0.59 (−0.74, 1.92) | −0.65 (−1.90, 0.60) | 0.36 (−1.35, 2.06) | −0.24 (−2.23, 1.75) | 0.78 (−1.33, 2.89) | −1.14 (−2.71, 0.42) |
| >25 | 1.86 (−0.04, 3.69) | 0.45 (−0.99, 1.90) | 1.60 (−0.39, 3.59) | 0.06 (−1.39, 1.51) | 2.43 (−2.49, 7.35) | 0.93 (−2.01, 3.87) |
| Total mood disturbance | ||||||
| BMI ≤20 | 2.33 (−1.46, 6.13) | 6.93 (2.16, 11.70) | 7;3.00 (−9.71, 15.71) | −1.00 (−3.48, 1.48) | – | 9.09 (3.70, 14.49) |
| 21–25 | −1.13 (−5.55, 3.30) | 3.67 (−0.49, 7.83) | −3.79 (−9.51, 1.94) | 0.56 (−2.41, 3.53) | 0.94 (−5.90, 7.79) | 7.38 (−1.17, 15.94) |
| >25 | −1.14 (− 5.54, 3.26) | −0.65 (− 3.55, 2.26) | −0.60 (− 6.49, 5.29) | 1.76 (−1.90, 5.43) | −2.29 (−10.66, 5.93) | −3.57 (−8.23, 1.08) |
*
Mean difference in score (index measurement – baseline measurement) with significant changes given in bold.