Table 2.

Blood pressure and heart rate during the drug-free and treatment periods

	Drug-free period	Nifedipine CR Treatment period	Difference (95% CI)	Drug-free period	Nifedipine retard Treatment period	Difference (95% CI)
24-h
Systolic BP, mmHg	149.3 ± 3.0	133.4 ± 2.6***	−22.0, −9.7	150.8 ± 3.7	139.7 ± 4.0***	−16.7, −5.5
Diastolic BP, mmHg	90.6 ± 1.5	81.8 ± 1.6***	−11.4, −6.1	95.6 ± 3.1	86.2 ± 2.4***	−12.8, −6.0
Heart rate, beats min−1	70.6 ± 1.3	71.4 ± 1.6	−2.5, 4.2	70.5 ± 1.8	74.4 ± 2.4*	−0.3, 8.1
RPP, mmHg·beats min−1·10−2	106.0 ± 2.8	95.9 ± 3.0***	−15.4, −4.8	106.8 ± 3.5	104.6 ± 4.2	−8.2, 3.8
Daytime (07.00–21.59 h)
Systolic BP, mmHg	155.1 ± 3.6	139.0 ± 2.6***	−22.6, −9.7	156.7 ± 3.9	147.9 ± 4.2***	−14.3, −3.3
Diastolic BP, mmHg	94.3 ± 1.7	85.2 ± 1.7***	−12.1, −6.1	99.3 ± 3.5	91.3 ± 2.9***	−11.7, −4.3
Heart rate, beats min−1	74.8 ± 1.7	75.1 ± 1.7	−3.5, 4.2	74.5 ± 2.2	78.8 ± 2.6**	0.5, 8.1
RPP, mmHg·beats min−1·10−2	116.3 ± 3.6	104.5 ± 2.7**	−18.2, −5.5	116.7 ± 4.3	116.7 ± 5.3	−6.2, 6.1
Nighttime (22.00–06.59 h)
Systolic BP, mmHg	139.6 ± 2.5	124.1 ± 3.4***	−23.0, −7.8	140.9 ± 3.9	126.1 ± 4.8***	−22.3, −7.2
Diastolic BP, mmHg	84.2 ± 1.5	76.1 ± 1.8***	−11.2, −5.0	89.3 ± 2.7	77.6 ± 2.2***	−15.4, −8.0
Heart rate, beats min−1	63.6 ± 1.3	65.2 ± 2.1	−2.4, 5.7	63.9 ± 1.7	67.1 ± 2.2	−2.2, 8.6
RPP, mmHg·beats min−1·10−2	88.6 ± 1.9	81.5 ± 4.2*	−14.5, 0.3	90.2 ± 2.9	84.4 ± 3.3	−12.6, 1.0

BP, Blood pressure; RPP, rate–pressure product.

^*P < 0.1;

^**P < 0.05;

^***P < 0.01 compared with drug-free period.