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Percentage change in systolic blood pressure vs ephedrine plasma concentration after oral dosing of ephedrine sulphate. (a) 0.25 mg kg−1 (grey diamonds), (b) 0.5 mg kg−1 (open circles), (c) 1.0 mg kg−1 (closed circles) and (d) representative model prediction for one subject after each dose (subject 4). Data shown as mean ± SD, n = 8. Symbols represent actual data and line represents model fit
