Figure 6.

Application of tolerance model for systolic blood pressure after administration of 50 mg ephedrine hydrochloride [11]. (a) Model fit from using pooled pharmacodynamic parameter estimates from this current study and study-specific pooled pharmacokinetic parameter estimates. (b) Model prediction using study-specific pharmacodynamic parameter estimates. Pharmacokinetic values: k_a = 1.27 h⁻¹, CL/F = 34.6 l h⁻¹, V/F = 306 l, t_lag = 9 min. Data shown as mean ± SD, n = 16. Symbols represent actual data and line represents model fit