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. 2004 May;57(5):552–562. doi: 10.1111/j.1365-2125.2003.02062.x

Statistical evaluation (i.e. AIC) of selected models used to evaluate the systolic blood pressure data. Models were tested on pooled data. Agonist-reverse agonist model described the data, statistically and graphically, better than other evaluated models

Pharmacodynamic Model for Blood Pressure Effects Equation AIC
Sigmoid EMAX graphic file with name bcp0057-0552-mu1.jpg 6045
Linear Tolerance [27] graphic file with name bcp0057-0552-mu2.jpg 6058
Agonist-Competitive Antagonist [37] graphic file with name bcp0057-0552-mu3.jpg 6112
Agonist-Partial Agonist [37] graphic file with name bcp0057-0552-mu4.jpg 6046
Agonist-Reverse Agonist [37] graphic file with name bcp0057-0552-mu5.jpg 6043