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Methods to evaluate applicability of tolerance model
| Scenario 1 ‘Blood pressure prediction’ | Scenario 2 ‘Model re-evaluation | |
|---|---|---|
| Pharmacokinetics (PK) | Study-specific | Study-specific |
| Pharmacodynamics (PD) | Predicted based on current study PD parameter estimates (Table 5) | Data modelled to convergence (i.e. obtain new set of parameter estimates) (Table 6) |
| Goal | To predict blood pressure response given blood concentrations | To re-evaluate PD parameters based on different experimental designs. |
