Table 3.

Summary of ephedrine pharmacokinetic parameters for all three doses of ephedrine sulphate (0.25, 0.50, 1.0 mg kg⁻¹)

Subject	ka (h−1)	CL/F(l h−1 kg−1)	V/F(l kg−1)	tlag (min)
1	1.30	0.39	4.4	5.2
2	0.94	0.46	4.4	13.2
3	1.50	0.38	4.5	12.6
4	0.96	0.51	4.5	6.1
5	0.89	0.50	4.6	2.4
6	0.84	0.37	3.4	8.7
7	0.86	0.43	3.6	5.5
8	0.29	0.72	2.5	2.1
Mean	0.95	0.47	4.0	7.0
SD	0.36	0.11	0.8	4.2
Pooled*	0.93	0.45	4.2	7.1

k_a, rate constant of absorption; CL/F, apparent oral clearance; V/F, apparent volume of distribution; t_lag, lag time;

^*parameter derived from modelling data from all subjects (n = 8).