Table 6.
Applicability of tolerance model to different data sets
| Emax(%Δ) | EC50 (µg l−1) | γe | Imax (%Δ) | IC50(µg l−1) | γi | ki0(h−1) | Imax/Emax | Dose | Synthetic or herbal | |
|---|---|---|---|---|---|---|---|---|---|---|
| Current study (n = 8) | 64.2 | 174 | 1.9 | 26.5 | 90.6 | 2.8 | 2.0 | 0.41 | 0.25, 0.5, 1.0 mg kg−1 | Synthetic |
| Berlin et al. (2001) (n = 16) | 54.3 | 143 | 1.7 | 20.4 | 74.4 | 1.9 | 0.8 | 0.38 | 50 mg | Synthetic |
| Haller et al. (2002) (n = 8) | 54.7 | 154 | 1.3 | 9.8 | 34.1 | 5.9 | 0.6 | 0.18 | 17.3 mga | Herbal |
Emax, maximum effect; EC50, plasma ephedrine concentration corresponding to one-half the maximum effect, γe, slope factor for the effect, Imax, maximum inhibitory effect; IC50, theoretical ‘inhibitor’ concentration corresponding to one-half the maximum inhibitory effect, γi, slope factor for the inhibitory effect; ki0, rate constant of tolerance development;
a
ephedrine also contained 175 mg caffeine.