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. 2000 Oct 31;97(23):12804–12809. doi: 10.1073/pnas.210350097

Figure 5.

Figure 5

Equivalent patterns of expression and of decreasing lesion size after treatment with GT and Bcl-2. (A) X-Gal-stained neurons (×100) in representative sections (counterstained with Cresyl violet) from a rat receiving GT (Upper) or Bcl-2 (Lower). Cell bodies and large diameter dendrites of granule cells in the superior blade of the dentate gyrus are visibly stained. (B) Percentage of total X-Gal-positive cells in 1-mm regions along the anterior/posterior (A/P) axis of the dentate gyrus (n = 9/group). Mean percentage of total lesion differed between areas [F(3,64) = 27.23, P < 0.001] but not between groups. Zero on the x axis refers to the injection site. (C) Percentage of X-Gal-positive cells on the superior blade of the dentate gyrus grouped into three equal regions along the medial/lateral (M/L) axis (n = 9/group). Mean percentage of total lesion differed between areas [F(2,48) = 10.01, P < 0.001] but not between groups. The number “1” on the x axis refers to the most medial third. (D) Percentage of total lesion in 1-mm regions along the A/P axis for hippocampi treated with KA and Glut-1 or Bcl-2 (n = 5/group). Mean percentage of total lesion differed between areas [F(3,32) = 18.22, P < 0.001], but not between groups. (E) Percentage of total lesion grouped into three equal regions along the M/L axis (n = 5/group). Mean percentage of total lesion differed between areas [F(2,24) = 51.93, P < 0.001], but not between groups. The number “1” on the x axis refers to the most medial third.