Table 3.
Heart rate response parameters in healthy subjects given FTY720 in the fasting or fed state
| Parameter | Fasting Placebo | FTY720 | Fed Placebo | FTY720 |
|---|---|---|---|---|
| Day 1 predose rate (beats min−1) | 64 ± 8 | 63 ± 7 | 65 ± 11 | 62 ± 9 |
| Morning nadir (beats min−1) | 55 ± 7 | 50 ± 4 | 55 ± 6 | 51 ± 6 |
| Morning time of nadir (h) | 2 (1–4) | 4 (4–8) | 2 (1–8) | 4 (4–8) |
| AUE(0,8 h) (beats min−1 × h) | 477 ± 56 | 443 ± 38 | 474 ± 45 | 454 ± 47 |
| Daily nadir (beats min−1) | 53 ± 6 | 47 ± 3 | 53 ± 6 | 49 ± 6 |
| Daily time of nadir (h) | 16 (1–20) | 20 (4–20) | 4 (2–20) | 10 (4–20) |
| AUE(0,24 h) (beats min−1 × h) | 1435 ± 152 | 1293 ± 115 | 1420 ± 128 | 1317 ± 138 |
| Day 2 morning rate (beats min−1) | – | 56 ± 5 | – | 56 ± 7 |
| Day 3 morning rate (beats min−1) | – | 59 ± 6 | – | 59 ± 7 |
| Day 4 morning rate (beats min−1) | – | 60 ± 8 | – | 63 ± 10 |
| Day 5 morning rate (beats min−1) | – | 61 ± 8 | – | 62 ± 7 |
Values are mean ± SD except for tnadir which is median (range). AUE is area under the heart rate vs time effect curve. Morning nadir taken from the time interval 0–8 h, daily data taken from the interval 0–24 h.