Table 2.
Pharmacokinetic parameters on the day of haemodialysis
| Dose (mg) | Cmax (ng ml−1) | tmax (h) | AUC (ng ml−1 h) | CL/F (l h−1) | Clearance with haemodialysis (ml min−1) | t1/2 (h) | MRT(h) |
|---|---|---|---|---|---|---|---|
| 25 | 8.48 | 5 | 86.8 | 288 | −6.72 | 33.3 | 28.2 |
| (4.37, 24.8) | (3, 6) | (35.6, 122) | (204, 702) | (−23.5, 14.5) | (11.9, 50.5) | (16.4, 36.7) | |
| 50 | 19.3 | 5 | 222 | 225 | 9.43 | 35.6 | 31.8 |
| (7.60, 50.6) | (2, 6) | (82.3, 357) | (140, 607) | (−0.2, 31.0) | (12.9, 44.5) | (15.9, 42.8) | |
| 100 | 27.2 | 5 | 375 | 266 | 15.3 | 38.2 | 29.8 |
| (15.0, 96.4) | (1.5, 6) | (205, 568) | (176, 488) | (-20.9, 117) | (33.7, 55.0) | (27.5, 48.6) |
Data are expressed as median (min, max). Cmax, tmax and clearance with haemodialysis were calculated from data obtained from all subjects for each dose. Data obtained from subject 7 were excluded from the calculations of AUC, CL/F, t1/2, and MRT. Cmax maximum plasma concentration; tmax time to reach maximum plasma concentration; AUC the area under the plasma concentration-time curve; CL/F the apparent clearance; t1/2 terminal half-life; MRT mean residence time.