Table 4.
Mean ± SD fluconazole pharmacokinetic parameters after intravenous injection of fosfluconazole in subjects with normal, mild, moderate or severe renal impairment
| Parameter | AUC (µg-h ml−1) | Cmax (µg ml−1) | Tmax (h) | t1/2 (h) | MRT (h) | CL/F (ml min−1 kg−1) | Ae48 (%) | CLR (ml min−1 kg−1) |
|---|---|---|---|---|---|---|---|---|
| Normal | 631.0 (628.5) | 12.3 (12.0) | 3.1 ± 1.07 | 36.5 ± 6.06 | 52.8 ± 9.79 | 0.35 ± 0.034 | 42.3 ± 16.65 | 0.21 ± 0.096 |
| (n = 6) | ± 60.31 | ± 2.96 | ||||||
| Mild | 727.2 (709.0) | 13.3 (12.9) | 3.9 ± 1.57 | 38.7 ± 11.95 | 56.4 ± 17.45 | 0.36 ± 0.092 | 44.4 ± 13.17 | 0.22 ± 0.070 |
| (n = 7) | ± 176.24 | ± 3.67 | ||||||
| Moderate | 1748.7 (1512.2) | 15.7 (15.6) | 3.4 ± 0.92 | 79.8 ± 46.46 | 115.7 ± 66.38 | 0.21 ± 0.133 | 25.1 ± 12.53 | 0.11 ± 0.082 |
| (n = 6) | ± 998.95 | ± 2.00 | ||||||
| Severe | 2317.2 (2232.0) | 12.5 (12.4) | 3.4 ± 0.66 | 129.8 ± 34.24 | 189.7 ± 49.03 | 0.11 ± 0.027 | 13.1 ± 5.93 | 0.05 ± 0.028 |
| (n = 6) | ± 692.19 | ± 1.24 |
AUC, Area under the plasma concentration vs. time curve between time zero and infinity; Cmax, maximum observed plasma concentration; Tmax, first time to Cmax; t1/2, terminal elimination phase half-life; MRT, mean residence time; CL/F, total plasma clearance; Ae48, amount excreted in the urine; CLR, renal clearance. The arithmetic mean (geometric mean) for AUC and Cmax, and the arithmetic means for all other parameters are presented.