a) Individual methacholine PC20 values as doubling dilution shift from respective baselines for CIC and FP, given first and second, respectively, in sequence. A positive value indicates an improvement from baseline, and a negative value indicates a deterioration from baseline. b) Individual methacholine PC20 values as doubling dilution shift from respective baselines for CIC and FP, given second and first, respectively, in sequence. A positive value indicates an improvement from baseline, and a negative value indicates a deterioration from baseline