Table 2. Fluconazole pharmacokinetic parameters on day 14 after multiple intravenous administration of 1000 mg fosfluconazole and 800 mg fluconazole.
| Parameter | Fosfluconazole dosing(n = 23) | Fluconazole dosing(n = 18) |
|---|---|---|
| AUC(0,24 h) (µg ml−1 h) | 572 (563) ± 100.5 | 608 (598) ± 115.4 |
| Cmax,ss (µg ml−1) | 32.1 (31.8) ± 4.38 | 33.6 (33.0) ± 6.11 |
| tmax,ss (h) | 2.5 (0.25, 6.0) | 4.0 (3.0, 8.0) |
| Cav,ss (µg ml−1) | 23.8 (23.5) ± 4.19 | 25.4 (24.9) ± 4.79 |
The median (range) for tmax,ssand the arithmetic mean (geometric mean) ± SD for the other parameters are presented. One subject who did not complete a study period was excluded from the fosfluconazole dosing group. Four subjects who did not complete a study period, one subject who received placebo instead of FLCZ on day 14, and one subject with technical problems during FLCZ infusion on day 14 were excluded from the fluconazole dosing group.