Table 2.
Summary of donepezil pharmacokinetic parameters in each donepezil HCl treatment group on days 1 and 15
| Mean (s.e.) | |||
|---|---|---|---|
| Parameter | Donepezil HCl only (n = 16) | Donepezil HCl + sertraline HCl (n = 16) | Difference as a percentage |
| Day 1 | |||
| AUC0–24 h (ng·h ml−1) | 94.2 (3.3) | 100.3 (3.7) | +6.5 |
| Cmax (ng ml−1) | 6.7 (0.29) | 7.5 (0.26)* | +11.3 |
| tmax (h) | 3.9 (0.31) | 3.6 (0.20) | −7.9 |
| Day 15 | |||
| AUC0–24 h (ng·h ml−1) | 426.7 (25.3) | 420.0 (19.0) | −1.6 |
| AUC0–∞ (ng·h ml−1) | 1541 (152) | 1461 (104) | −5.2 |
| Cmax (ng ml−1) | 24.4 (1.3) | 25.4 (1.1) | +4.2 |
| tmax (h) | 3.1 (0.20) | 3.0 (0.18) | −2.0 |
| t1/2 (h) | 56.0 (2.4) | 54.9 (2.2) | −1.9 |
| Css (ng ml−1) | 17.78 (1.05) | 17.50 (0.79) | −1.6 |
*
P < 0.05 for donepezil HCl vs. donepezil HCl + sertraline HCl.