Table 3.
Summary of sertraline pharmacokinetic parameters in each sertraline HCl treatment group on days 1 and 15
| Mean (s.e.) | |||
|---|---|---|---|
| Parameter | Sertraline HCl only (n = 16) | Donepezil HCl + sertraline HCl (n = 16) | Difference as a percentage |
| Day 1 | |||
| AUC0–24 h (ng·h ml−1) | 172.5 (20.9) | 183.8 (12.9) | +6.6 |
| Cmax (ng ml−1) | 12.1 (1.3) | 13.8 (0.98) | +14.1 |
| tmax (h) | 7.0 (0.26) | 6.8 (0.25) | −3.6 |
| Day 15 | |||
| AUC0–24 h (ng·h ml−1) | 934.0 (134.0) | 883.9 (145.0) | −5.4 |
| AUC0–∞ (ng·h ml−1) | 2167 (392) | 2192 (586) | +1.2 |
| Cmax (ng ml−1) | 55.1 (7.6) | 50.9 (7.6) | −7.6 |
| tmax (h) | 6.9 (0.26) | 6.6 (0.34) | −4.6 |
| t1/2 (h) | 27.5 (1.5) | 28.4 (2.1) | +3.5 |
| Css (ng ml−1) | 38.9 (5.6) | 36.8 (6.0) | −5.4 |