Table 4.
Clearance of vancomycin and urea by CVVHDF
| Patient profile | AUCCVVHDF (mg h l−1) | ACVVHDF (mg) | ClCVVHDF (l h−1) | FCVVHDF | CLurea (l h−1) |
|---|---|---|---|---|---|
| 1A | 243.4 | 366.5 | 1.5 | 69 | 2.2 |
| 1B | 256.8 | 360 | 1.4 | 78 | 1.8 |
| 2A | 210.6 | 338.3 | 1.6 | 76 | 2.2 |
| 2B | 76.3 | 79.4 | 1.0 | 43 | 1.7 |
| 3A | 196.8 | 389 | 2.0 | 71 | 2.5 |
| 3B | 367.6 | 696 | 1.9 | 95 | 2.0 |
| 4B | 243.9 | 538.4 | 2.2 | 71 | 2.3 |
| 5A | 243.6 | 376.3 | 1.5 | 100 | 1.9 |
| 6B | 300.8 | 578.6 | 1.9 | 76 | 2.2 |
| 7B | 350.1 | 723.7 | 2.1 | 100 | 2.2 |
| 8A | 190.6 | 344.4 | 1.8 | 82 | 2.3 |
| 8B | 283.8 | 655.6 | 2.3 | 88 | 2.2 |
| 9B | 171.9 | 352 | 2.1 | 48 | 2.2 |
| 10A | 115.6 | 260.6 | 2.3 | 64 | 2.4 |
| 10B | 67.8 | 135.5 | 2.0 | 77 | 2.4 |
| Mean ± SD | – | 413 ± 191 | 1.8 ± 0.4 | 76 ± 16.5 | 2.2 ± 0.2 |
AUCCVVHDF, Area under the curve while CVVHDF operating; ACVVHDF, amount of vancomycin removed by CVVHDF in dosing interval; CLCVVHDF, clearance of vancomycin through the filter; FCVVHDF, fraction of vancomycin eliminated by CVVHDF while operating; Clurea, clearance of urea through the filter.