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. 2004 Sep;58(3):277–287. doi: 10.1111/j.1365-2125.2004.02156.x

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© 2004 Blackwell Publishing Ltd

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Inhibition of domperidone (5 µm) metabolism by HLMs. The selective inhibitors used were furafylline (10 µm) for CYP1A2, thioTEPA (50 µm) for CYP2B6, sulfaphenazole (50 µm) for CYP2C9, omeprazole (10 µm) and ticlopidine (5 µm) for CYP2C19, quinidine (1 µm) for CYP2D6, diethyldithiocarbamate (DEDTC, 50 µm) for CYP2E1 and ketoconazole (1 µm) and troleandomycin (50 µm) for CYP3A. Inhibition data are expressed as percent control activity remaining (mean ± s.d. of 3 different experiments in duplicate). MIII (▪), MII (□), MI ()

Inline graphic — Inhibition of domperidone (5 µm) metabolism by HLMs. The selective inhibitors used were furafylline (10 µm) for CYP1A2, thioTEPA (50 µm) for CYP2B6, sulfaphenazole (50 µm) for CYP2C9, omeprazole (10 µm) and ticlopidine (5 µm) for CYP2C19, quinidine (1 µm) for CYP2D6, diethyldithiocarbamate (DEDTC, 50 µm) for CYP2E1 and ketoconazole (1 µm) and troleandomycin (50 µm) for CYP3A. Inhibition data are expressed as percent control activity remaining (mean ± s.d. of 3 different experiments in duplicate). MIII (▪), MII (□), MI ()