Table 1.
Size descriptors used in pharmacokinetic studies
| Subject demographics from where size descriptor derived | ||||||
|---|---|---|---|---|---|---|
| Size descriptor | Formula | Weight − kg mean ± SD (range) | Height – m mean ± SD (range) | |||
| Body mass index (BMI), kg m−2 | Males = 7426 [15] | |||||
| TBW/HT (m)2 | 69.5 ± 10.5* | 1.69 ± 0.062* | ||||
| Body surface area (BSA), m2 | Male / females = 43 [17] | |||||
| TBW0.425 × HT (cm)0.725 × 0.007184 | 52.4 ± 18.5(6.27 – 93.0) | 1.61 ± 0.204(0.782 – 1.87) | ||||
 [19] |
||||||
| Ideal body weight (IBW), kg | Males [26] | |||||
| Tables dependent on frame size and height | (29.5 – 156) | (1.47 – 2.01) | ||||
| Females [26] | ||||||
| Devines estimation = 45.4 + 0.89 × (HT (cm) − 152.4) + 4.5 (if male) [28] | (29.5 – 156) | (1.37 – 1.91) | ||||
| Fat-free mass (FFM), kg | Males = 24 [36] | |||||
| 0.285 × TBW + 12.1 × HT (m)2 for males | 80.3 ± 22.0(43.5 – 126) | 1.72 ± 0.07(1.57 – 1.86) | ||||
| Females = 104 [36] | ||||||
| 0.287 × TBW + 9.74 × HT (m)2 for females | 91.7 ± 19.5(42.3 – 133.5) | 1.63 ± 0.07(1.44 – 1.79) | ||||
| Lean body weight (LBW), kg | Males = 89 | |||||
| 1.1 × TBW − 0.0128 × BMI × TBW for males | 68.0 ± 9.86(47.2 – 92.3) [49] | NR | ||||
| 71.8 ± 17.1(36.4 – 122) [30] | ||||||
| 68.0(57.0 – 81.2) [50] | ||||||
| Females = 44 | ||||||
| 1.07 × TBW − 0.0148 × BMI × TBW for females | 54.7 ± 7.12(45.4 – 62.4) [49] | |||||
| 64.7 ± 23.5(32.3 – 108) [30] | NR | |||||
| 57.0(44.4 – 68.3) [50] | ||||||
| Adjusted body weight(ABW), kg | Males = 24, females = 24 | |||||
| IBW + CF × (TBW − IBW)CF = correction factor of 0.4 | Gentamicin | |||||
| Obese = 138.3 ± 15.2 | ||||||
| Normal = 73.2 ± 7.5 | ||||||
| Amikacin | ||||||
| Obese = 151.1 ± 17.2 | ||||||
| Normal = 71.0 ± 8.5 | ||||||
| Tobramycin | ||||||
| Obese = 147.3 ± 16.3 | ||||||
| Normal = 72.4 ± 4.2 | ||||||
| Percent IBM (%IBW), % |  |
N/A [42] | ||||
| Subject demographics from where size descriptor derived | Weight − kg | Height − m | ||||
| Size discriptor | Formula | mean ± SD (range) | mean ± (range) | |||
| Predicted normal weight(PNWT), kg | Males = 1226 [10] | |||||
| 1.57 × TBW − 0.0183 × BMI × TBW − 10.5 for males | 72.7 ± 11.9(36.0 – 112) | 1.72 ± 7.88(1.47 – 1.96) | ||||
| Females = 1121 [10] | ||||||
| 1.75 × TBW – 0.0242 × BMI × TBW – 12.6 for females | 61.8 ± 9.77(25.2 – 95.0) | 1.62 ± 6.83(137 – 182) | ||||
TBW = total body weight (kg), HT = height.NA = not applicable, NR = not reported.
*
Mean of pooled mean weights / heights / SD from the 12 recruitment centres.