Table 1. Time-varying covariates gentamicin data set, based on observed values of the covariate within an individual.

Covariate	Symbol	Mean	Median	Range	SD	No. of covariate measurements	No. of patients	No. of associated concentration measurements
Creatinine clearance (ml min−1)	CLC	81.9	76.9	14.8–183	32.2	576	210	574
Baseline	BCLC	77.4	71.7	14.8–180	31.2	210		350
Delta	DCLC	0.4	1.4	−65.8–79.4	18.6	366	132	224
Albumin (g/litre)	ALB	33.5	34.0	14.0–53.0	5.9	439	210	574
Baseline	BALB	33.9	35.0	14.0–47.0	6.1	210		373
Delta	DALB	−2.2	−2.0	−16.0–13.0	5.4	229	97	201
Body surface area (m2)	BSA	1.7	1.7	1.3–2.3	0.2	248	210	574
Baseline	BBSA	1.8	1.7	1.3–2.3	0.2	210		481
Delta	DBSA	0.0	0.0	−0.2–0.1	0.1	38	29	93