Table 2. Time-varying covariates pefloxacin data set, based on observed values of the covariate within an individual.
| Covariate | Symbol | Mean | Median | Range | SD | No. of covariate measurements | No. of patients | No. of associated concentration measurements |
|---|---|---|---|---|---|---|---|---|
| Creatinine clearance (ml min−1) | CLC | 113.2 | 103.5 | 0.43–312.0 | 72.6 | 114 | 74 | 337 |
| Baseline | BCLC | 109.7 | 104.5 | 0.43–312.0 | 70.1 | 74 | 220 | |
| Delta | DCLC | 16.5 | 12.6 | −127.5–203.3 | 62.6 | 40 | 37 | 117 |
| Bilirubin (µmol/litre) | BIL | 34.7 | 21.0 | 4.0–150.0 | 35.2 | 110 | 74 | 337 |
| Baseline | BBIL | 35.5 | 21.0 | 6.0–150.0 | 35.5 | 74 | 229 | |
| Delta | DBIL | −3.1 | −1.5 | −69.0–40.0 | 23.4 | 36 | 34 | 108 |
| Weight (kg) | WT | 69.0 | 67.0 | 42.7–125.0 | 13.6 | 103 | 74 | 337 |
| Baseline | BWT | 68.8 | 67.0 | 42.7–125.0 | 12.8 | 74 | 247 | |
| Delta | DWT | −2.4 | −3.0 | −16.0–7.6 | 4.8 | 29 | 28 | 90 |