Table 3. Time-varying covariates voriconazole data set, based on observed values of the covariate within an individual.

Covariate	Symbol	Mean	Median	Range	SD	No. of covariate measurements	No. of patients	No. of associated concentration measurements
Alanine amino transferase (IU/litre)	ALT	49.3	25	7–535	75.0	77	35	355
Baseline	BALT	34.9	25	7–159	31.9	35		235
Delta	DALT	27.1	2.5	−136–437	87.2	42	25	120
Alkaline phosphatase (IU/litre)	ALKP	161.4	130	47–761	107.9	76	34	355
Baseline	BALKP	148.7	136	47–309	62.3	34		240
Delta	DALKP	−1.5	−13	−101–453	88.3	42	23	115