Table 7. Reference and final model parameters (RSE) for voriconazole.
| Reference model | Final model | |
|---|---|---|
| OFV | 141.9 | 112.1 |
| ΔOFV | −29.8 | |
| θCL | 0.40 (14%) | 0.36 (11%) |
| θpm-CL | 0.46 (32%) | 0.46 (31%) |
| θlog(ALKP)-CL | 0.35 (3.4%) | − |
| θlog(DALKP)-CL | – | 0.59 (64%) |
| θlog(ALT)-CL | 0.28 (20%) | 0.75a (26%) |
| θV1 | 0.80 (20%) | 0.78 (23%) |
| θQ | 0.64 (15%) | 0.62 (25%) |
| θV2 | 1.7 (7.5%) | 1.62 (11%) |
| σ | 0.46 (20%) | 0.42 (20%) |
| ωCL | 0.67 (10%) | 0.61 (11%) |
| ωlog(ALT) | – | 0.30b (61%) |
| ωlog(DALKP) | – | 1.94 (21%) |
| ωσ | 0.77 (32%) | 0.77 (33%) |
a
Constrained 0.66*θlog(ALT)-0.33 = 0.23.
b
Approximate SD from logit transformation.