Table 8. Reference and final model parameters (RSE) for paclitaxel myelosuppression.
| Reference model | Final model | |
|---|---|---|
| OFV | 1062.4 | 1004.7 |
| ΔOFV | −57.7 | |
| θCirc0 | 5.2 (3.6%) | 5.47 (4.4%) |
| θMTT | 127 (2.1%) | 131 (3.6%) |
| θBIL-MTT | – | –0.012 (13%) |
| θγ | 0.23 (2.8%) | 0.22 (8.9%) |
| θSlope | 44.2 (4.5%) | 48.6 (8%) |
| θDBIL-Slope | – | –0.034 (25%) |
| ωCirc0 | 0.35 (11%)a | 0.36 (33%)a |
| ωMTT | 0.18 (30%)a | 0.17 (32%)a |
| ωSlope | 0.43 (32%)a | 0.38 (27%)a |
| ωDBIL-slope | – | 0.89 (41%)a |
| σ | 0.40 (9.3%) | 0.38 (9.9%) |
a
The RSE is relative to the corresponding variance term (ω2).