Table 2. Individual and mean pharmacokinetic parameters after intravenous administration of 2 µg desmopressin to healthy subjects and to patients with varying degrees of renal impairment. The subjects were divided into four groups, based on the quantiles of the creatinine clearance (CrCL).

ID	CrCL (ml min−1)	CL (litres h−1)	CLr (litres h−1)	Vss (litres)	t1/2( λ1) (h)	t1/2( λ2) (h)	t1/2(λ3) (h)	fe
Group 1
24	88	13	5.3	46	0.18	1.2	3.5	0.42
5	90	8.1	3.4	34	0.12	1.0	4.0	0.41
17	90	7.0	3.4	33	0.12	1.0	4.3	0.48
23	101	16	7.5	51	0.20	1.2	3.1	0.46
21	102	8.8	4.8	31	0.10	0.86	3.6	0.55
19	144	9.8	4.8	35	0.13	0.99	3.6	0.49
Mean	103	10	4.9	38	0.14	1.0	3.7	0.47
SD	21	3.4	1.5	8.1	0.04	0.13	0.41	0.05
CV%	21	33	32	21	28	13	11	11
Group 2
3	66	6.7	2.4	46	0.19	1.3	5.6	0.36
2	67	7.5	2.6	43	0.17	1.2	4.8	0.35
1	68	6.2	2.7	38	0.14	1.2	5.1	0.43
4	75	6.5	2.7	31	0.10	0.94	4.4	0.43
6	82	7.8	3.6	34	0.12	1.0	4.1	0.47
Mean	72	6.9	2.8	38	0.15	1.1	4.8	0.41
SD	6.8	0.68	0.48	6.3	0.04	0.2	0.59	0.05
CV%	10	10	17	16	24	14	12	12
Group 3
8	29	3.1	0.76	33	0.12	1.1	8.2	0.24
7	33	8.4	1.3	80	0.38	1.7	7.3	0.16
12	33	3.9	0.96	36	0.14	1.2	7.3	0.25
14	35	3.8	1.1	38	0.15	1.2	7.7	0.29
9	54	5.2	1.8	33	0.12	1.1	5.4	0.34
Mean	37	4.9	1.2	44	0.18	1.3	7.2	0.26
SD	9.9	2.1	0.38	20	0.11	0.2	1.1	0.07
CV%	27	43	33	46	62	19	15	26
Group 4
16	10	1.9	0.32	42	0.17	1.4	16	0.17
18	12	2.1	0.35	30	0.10	1.1	11	0.17
22	12	3.4	0.42	47	0.20	1.4	10	0.12
15	14	2.9	0.65	32	0.12	1.1	8.8	0.23
11	23	4.0	1.1	42	0.17	1.3	8.1	0.27
13	26	3.3	1.0	36	0.14	1.2	8.4	0.31
Mean	16	2.9	0.65	38	0.15	1.3	10	0.21
SD	6.6	0.82	0.35	6.4	0.04	0.13	2.9	0.07
CV%	41	28	54	17	24	10	28	34

CrCL = creatinine clearance; CL = clearance; CL_r = renal clearance; V_ss = volume of distribution at steady state; t_1/2λ1 = half-life for the first distribution phase; t_1/2λ2 = half-life for the second distribution phase; t_1/2λ3 = half-life for the terminal phase; fe = fraction of the dose excreted in the urine.