Figure 1.

(A) Mean plasma concentrations of repaglinide in 12 healthy volunteers after a single 0.25 mg oral dose of repaglinide, alone or with 400 mg bezafibrate or 200 mg fenofibrate once daily for 5 days. ○, repaglinide alone; ▪, repaglinide with bezafibrate; ▴, repaglinide with fenofibrate. For clarity, only mean values are presented. Mean (± SD) plasma concentrations of (B) bezafibrate and (C) fenofibrate after the last dose, in their respective phases. Time zero in Figures B and C refers to administration of the fibrates, i.e. 1 h before the administration of repaglinide (R)