Table 2.
First dose predictions of gentamicin using SeBA-GEN, DoseCalc and the First Dose Table (Table 1). The prescribed dose is provided for comparison
| P-value for method† | |||||
|---|---|---|---|---|---|
| Method | Dose (mg)* | SeBA-GEN | DoseCalc | First Dose Table | Prescribed dose |
| CLCr = 30–60 ml min−1; n = 25 (moderate renal impairment) | |||||
| SeBA-GEN | 240 (224, 256) | – | <0.001 | NS | NS |
| DoseCalc | 144 (116, 172) | <0.001 | – | <0.001 | <0.001 |
| First Dose Table | 241 (223, 259) | NS | <0.001 | – | NS |
| Prescribed dose | 272 (240, 304) | NS | <0.001 | NS | – |
| CLCr = 60–90 ml min−1; n = 44 (mild renal impairment) | |||||
| SeBA-GEN | 352 (339, 365) | – | NS | 0.048 | 0.006 |
| DoseCalc | 358 (329, 387) | NS | – | 0.007 | 0.048 |
| First Dose Table | 327 (313, 341) | 0.048 | 0.007 | – | <0.001 |
| Prescribed dose | 383 (367, 399) | 0.006 | 0.048 | <0.001 | – |
| CLCr >90 ml min−1; n = 15 (normal renal function) | |||||
| SeBA-GEN | 497 (460, 534) | – | NS | <0.001 | NS |
| DoseCalc | 512 (484, 540) | NS | – | <0.001 | NS |
| First Dose Table | 382 (366, 398) | <0.001 | <0.001 | – | <0.001 |
| Prescribed dose | 501 (475, 527) | NS | NS | <0.001 | – |
*
Data are mean (95% CI); n = 84 complete sets of data.
†
One-way RM anova; Tukey test. To compare the methods, read down the column (or across the row) to the desired comparator row (or column).