Table 2.
Relative prevalence of various covariates that influence the pharmacokinetics
| Covariate | Young adults | Elderly |
|---|---|---|
| Liver disease/CYP3A4 | + | ++ |
| Genetics/CYP2D6 | + | + |
| Genetics/CYP2C9/19 | + | + |
| Renal disease | + | +++ |
| Cardiac disease | – | ++ |
| Polypharmacy | + | ++++ |
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