Table 2.
Physiological and pathophysiological functions of COX isoforms 1 and 2 – modified according to [7]
| COX-1 | COX-2 | |
|---|---|---|
| Physiological functions | ||
| GI mucosal protection | X | |
| Kidney function | X | X |
| Kidney development | X | |
| Reproduction | X | |
| Regulation of blood flow | X | X |
| CNS function | X | X |
| Bone metabolism | X | X |
| Lung function | X | ? |
| Platelet aggregation | X | |
| Pathophysiological functions | ||
| Inflammatory signs | X | X |
| Inflammation resolution | X | |
| GI mucosal protection under inflammatory conditions | X | X |
| Gastric ulceration | X* | X* |
| Tissue repair/ulcer healing | X | |
| (gastrointestinal) Cancer | X | X |
*
Inhibition of both isoforms necessary.