Skip to main content
. 2007 Jun 7;117(7):1961–1967. doi: 10.1172/JCI29877

Figure 4. Effect of S1179D and S1179A mutations on vascular reactivity.

Figure 4

(A) Left common carotid arteries were constricted with phenylephrine (10–5 M) and then subjected to increasing doses of ACh from 1 × 10–9 to 1 × 10–5 M. S1179A/eNOS KO mice, n = 8; S1179D/eNOS KO mice, n = 8; eNOS KO mice, n = 6; and WT mice, n = 8. *P < 0.01 by 1-way ANOVA; †P < 0.05 by 1-way ANOVA. (B) Left common carotid arteries were treated with l-NAME (3 × 10–4 M) for 30 minutes, constricted with phenylephrine (10–5 M), and then subjected to increasing doses of SNP from 1 × 10–9 to 1 × 10–5 M. Data are expressed as mean ± SEM.