Table 3.
Population pharmacokinetic parameters for abacavir in 188 adult patients and the results of bootstrap validation
| Final model | ||||
|---|---|---|---|---|
| Original dataset | Bootstrap† | |||
| Parameter | Mean | SE | Mean | SE |
| TV (CL/F) (l h−1) | 47.5 | 2.6 | 46.8 | 4.0 |
| CL/F, θBW | 0.80 | 0.23 | 0.77 | 0.27 |
| TV(Vc/F) (l) | 75 | 7.7 | 70.5 | 13.4 |
| TV (Q/F) (l h−1) | 10* | 2.3* | / | / |
| TV(Vp/F) (l) | 24 | 3.5 | 24.3 | 3.5 |
| TV(Ka) (h−1) | 1.8 | 0.4 | 2.0 | 1.1 |
| Residual variability, σ2 (mg l−1) | 0.039 | 0.009 | 0.039 | 0.010 |
| ω2CL/F | 0.18 | 0.03 | 0.18 | 0.03 |
| ω2Vc/F | 0.51 | 0.13 | 0.54 | 0.25 |
| ω2Ka | 1.13 | 0.33 | 1.11 | 0.37 |
| COVCL,V | 0.27 | 0.04 | 0.28 | 0.10 |
†
Mean of 1000 bootstrap analyses
SE, standard error of the estimate; TV(CL/F), TV(Vc/F) and TV(Ka), typical value of CL/F, Vc/F and Ka, respectively; θCOVARIATE, influential factor for covariate: BW, body weight; ω2, interindividual variability; COVCL,V, covariance between CL/F and Vc/F;
*
typical value and SE obtained with the basic model