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. 2005 Feb;59(2):239–243. doi: 10.1111/j.1365-2125.2004.02188.x

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Creatinine clearance for males and females vs. number of target drugs, P for trend (for both males and females combined) <0.001. Decreased creatinine clearance for both sexes on one, two and three target drugs P < 0.001, decreased creatinine clearance for males on two target drugs P < 0.05 and three target drugs P < 0.001, decreased creatinine clearance for females on one, two and three target drugs P < 0.001, significant difference between males and females on the same number of target drugs: one target drug P < 0.05, two target drugs P = 0.001. Male (), female ()

Inline graphic — Creatinine clearance for males and females vs. number of target drugs, P for trend (for both males and females combined) <0.001. Decreased creatinine clearance for both sexes on one, two and three target drugs P < 0.001, decreased creatinine clearance for males on two target drugs P < 0.05 and three target drugs P < 0.001, decreased creatinine clearance for females on one, two and three target drugs P < 0.001, significant difference between males and females on the same number of target drugs: one target drug P < 0.05, two target drugs P = 0.001. Male (), female ()