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Non-compartmental pharmacokinetic parameters (mean ± SD) of fentanyl following sublingual administration to eight cancer patients
| 100 µg | 200 µg | 400 µg | |
|---|---|---|---|
| AUC0–∞(ng ml−1 min−1) | 74.3 ± 31.0 | 159.1 ± 39.2 | 290.8 ± 92.5 |
| Cfirst (ng ml−1) | 0.05 ± 0.03 | 0.08 ± 0.08 | 0.17 ± 0.14 |
| tfirst (min) | 10.7 ± 3.2 | 8.0 ± 2.7 | 9.0 ± 4.1 |
| Cmax (ng ml−1) | 0.24 ± 0.14 | 0.41 ± 0.16 | 0.91 ± 0.3 |
| tmax (min) | 39.7 ± 17.4 | 48.7 ± 26.3 | 56.7 ± 24.6 |
| t½12 (h) | 6.1 ± 2.0 | 6.3 ± 1.6 | 5.4 ± 1.7 |
